Physical and functional definition of the Drosophila Notch locus by P element transformation.

@article{Ramos1989PhysicalAF,
  title={Physical and functional definition of the Drosophila Notch locus by P element transformation.},
  author={Ricardo G.P. Ramos and Barbara Grimwade and Keith A. Wharton and T N Scottgale and S. Artavanis-Tsakonas},
  journal={Genetics},
  year={1989},
  volume={123 2},
  pages={337-48}
}
Notch is a developmentally regulated locus which controls the differentiation of various Drosophila tissues, among them the embryonic nervous system. Molecular analysis has suggested that Notch is defined by an approximately 40-kb transcription unit which is spliced into a 10.2-kb mRNA composed of nine exonic regions and coding for a 2703-amino acid long transmembrane protein that shows homology to the mammalian epidermal growth factor. Here, we define the 5' end of the transcription unit and… CONTINUE READING