Physical and chemical effects of red cells in the shear-induced aggregation of human platelets.

@article{Goldsmith1995PhysicalAC,
  title={Physical and chemical effects of red cells in the shear-induced aggregation of human platelets.},
  author={Harry L. Goldsmith and David N Bell and S Braovac and Angela Steinberg and Fiona A. McIntosh},
  journal={Biophysical journal},
  year={1995},
  volume={69 4},
  pages={1584-95}
}
Both chemical and physical effects of red cells have been implicated in the spontaneous aggregation of platelets in sheared whole blood (WB). To determine whether the chemical effect is due to ADP leaking from the red cells, a previously described technique for measuring the concentration and size of single platelets and aggregates was used to study the shear-induced aggregation of platelets in WB flowing through 1.19-mm-diameter polyethylene tubing in the presence and absence of the ADP… CONTINUE READING

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