Physical and biochemical regulation of integrin release during rear detachment of migrating cells.

@article{Palecek1998PhysicalAB,
  title={Physical and biochemical regulation of integrin release during rear detachment of migrating cells.},
  author={Sean P Palecek and Anna Huttenlocher and Alan F. Horwitz and Douglas A. Lauffenburger},
  journal={Journal of cell science},
  year={1998},
  volume={111 ( Pt 7)},
  pages={929-40}
}
Cell migration can be considered as a repeated cycle of membrane protrusion and attachment, cytoskeletal contraction and rear detachment. At intermediate and high levels of cell-substratum adhesiveness, cell speed appears to be rate-limited by rear detachment, specifically by the disruption of cytoskeleton-adhesion receptor-extracellular matrix (ECM) linkages. Often, cytoskeletal linkages fracture to release integrin adhesion receptors from the cell. Cell-extracellular matrix bonds may also… CONTINUE READING