Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.

@article{Tennent1989PhysicalAB,
  title={Physical and biochemical characterization of the qacA gene encoding antiseptic and disinfectant resistance in Staphylococcus aureus.},
  author={Jan M. Tennent and Bruce R. Lyon and Mary Midgley and I. Gwyn Jones and A S Purewal and Ronald A. Skurray},
  journal={Journal of general microbiology},
  year={1989},
  volume={135 1},
  pages={1-10}
}
We have previously cloned a 3.5 kb fragment from the Staphylococcus aureus multiresistance plasmid pSK1 which carries the qacA determinant responsible for linked resistance to acriflavine (Acr), ethidium bromide (Ebr), quaternary ammonium compounds (Qar), propamidine isethionate (Pir), and diamidinodiphenylamine dihydrochloride (Ddr). This report presents a biochemical and physical analysis of qacA and shows the widespread carriage of this gene on S. aureus resistance plasmids. Tn5 insertion… CONTINUE READING
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