18 Citations
Characterising the reprogramming dynamics between human pluripotent states
- Biology
- 2019
It is found that naïve cells are formed at a much earlier time point than previously realised, and could be subsequently isolated from a heterogeneous cell population early during reprogramming, and reveal for the first time the order of transcriptional and epigenetic changes associated with primed to naïve reprograming.
Detection and quantification of the vacuolar H+ATPase using the Legionella effector protein SidK
- BiologybioRxiv
- 2021
It is shown that V-ATPases are acquired progressively during phagosome maturation, that they distribute in discrete membrane subdomains, and that their density in lysosomes depends on the subcellular localization of the lysOSome.
Data on known anti-virals in combating CoVid-19
- ChemistryBioinformation
- 2020
The potential use of ivermectin and remdesivir in the management of CoVid -19 is documented and it is shown that IvermECTin and remedesivir repress the replication of SARS-CoV-2.
In-line treatments and clinical initiatives to fight against COVID-19 outbreak
- MedicineRespiratory Medicine
- 2020
Cytotoxic T cells and Cancer Therapy
- Biology
- 2017
Pre-eminent role of CTLs in combating cancer can be effectively applied for the active and passive immunotherapeutic approaches and design and development of vaccines based on such immunogenic candidates can be executed.
Three-Dimensional Display Technologies for Anatomical Education: A Literature Review
- EducationJournal of Science Education and Technology
- 2016
Anatomy is a foundational component of biological sciences and medical education and is important for a variety of clinical tasks. To augment current curriculum and improve students’ spatial…
Three-Dimensional Display Technologies for Anatomical Education: A Literature Review
- Education
- 2016
Anatomy is a foundational component of biological sciences and medical education and is important for a variety of clinical tasks. To augment current curriculum and improve students’ spatial…
Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats
- Biology, PsychologyNeuropsychopharmacology
- 2016
The results suggest that predator threat triggers long-term changes in 2-AG-mediated endocannabinoid signaling in the amygdala, and that pharmacological interventions targeting MGL might provide a therapeutic strategy for the treatment of chronic brain disorders initiated by trauma.
On aging and the role of Ubp3 in heterochromatic gene silencing and protein quality control
- Biology
- 2014
It is shown that cells lacking Ubp3 are short-lived despite displaying decreased unequal recombination at rDNA and increased silencing at all three heterochromatic regions in S. cerevisiae subjected to transcriptional silencing, and that Sir2-deficient cells display increased daughter cell inheritance of stress and age-induced misfolded proteins deposited in aggregates and inclusion bodies.