Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence

@article{Harwood2009PhysicalAA,
  title={Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence},
  author={Ceryl A Harwood and Christopher J Mcdermott and Pamela J. Shaw},
  journal={Amyotrophic Lateral Sclerosis},
  year={2009},
  volume={10},
  pages={191 - 204}
}
Motor neuron disease (MND) is a devastating neurodegenerative condition associated with considerable disability and a poor prognosis. Despite improvements in symptomatic management in recent years, few therapies are available which modify survival. However, the challenge to find successful treatments would be greatly assisted by clearer elucidation of the underlying pathoaetiology. Many potential exogenous risk factors have been proposed as part of a gene-environment interaction in the… 
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References

SHOWING 1-10 OF 146 REFERENCES
An Evidence-Based Medicine Approach to the Evaluation of the Role of Exogenous Risk Factors in Sporadic Amyotrophic Lateral Sclerosis
TLDR
Evidence supported the conclusion that the following were probably not risk factors for ALS: trauma, physical activity, residence in rural areas and alcohol consumption, and evidence in support of smoking being a probable (‘more likely than not’) risk factor for ALS.
Amyotrophic lateral sclerosis in an Italian professional soccer player.
TLDR
The overall available clinical and epidemiological evidence supports the possible relation between the specific occupational environment (soccer) and the occurrence of ALS in this patient.
Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target.
TLDR
The evidence implicating oxidative stress in ALS pathogenesis is reviewed, how oxidative stress may affect and be affected by other proposed mechanisms of neurodegeneration, and the trials of various anti-oxidants as potential therapies for ALS are reviewed.
Sports and trauma in amyotrophic lateral sclerosis revisited
  • C. Armon
  • Medicine
    Journal of the Neurological Sciences
  • 2007
TLDR
The new data support the previous conclusions that physical activity and trauma are probably ("more likely than not") not risk factors for ALS and the theoretical framework for a "healthy worker effect" on incidence of neurodegenerative diseases in cohorts of employed or formerly employed individuals is developed.
Excitotoxicity and Amyotrophic Lateral Sclerosis
TLDR
The intrinsic properties of motor neurons that render these cells particularly vulnerable to excitotoxicity and could explain the selective vulnerability ofMotor neurons in ALS are summarized to help to develop new and better therapeutic strategies that could protect motor neurons from excitOToxicity.
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study
TLDR
A genetic variant in the inositol 1,4,5-triphosphate receptor 2 gene (ITPR2) is a strong candidate susceptibility gene for ALS because it is involved in glutamate-mediated neurotransmission, is one of the main regulators of intracellular calcium concentrations, and has an important role in apoptosis.
Rising mortality due to Parkinson's disease and amyotrophic lateral sclerosis: a manifestation of the competitive nature of human mortality.
TLDR
When the rise in PD and ALS mortality is viewed from the perspective of deterministic and competitive mortality dynamics, it becomes evident that the major force increasing mortality from these two neurologic diseases is the declining mortality from IHD and stroke.
Oxidative damage to protein in sporadic motor neuron disease spinal cord
The recent discovery that defects in the gene encoding copper‐zinc superoxide dismutase (SOD1) are associated with some cases of familial motor neuron disease has heightened interest in the
Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS)
  • M. Muddasir Qureshi, D. Hayden, +7 authors M. Cudkowicz
  • Psychology, Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2006
TLDR
D disease progression was faster in the ALS subjects having bulbar onset and a shorter time period between onset of symptoms and diagnosis, and significant risk factors for ALS included reported exposure to lead and pesticides.
Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?
TLDR
The literature would still support the concept of soccer, head trauma, and ALS being interrelated, with high levels of athleticism/physical activity perhaps playing an additive part.
...
1
2
3
4
5
...