Physical activity-antidepressant treatment combination: impact on brain-derived neurotrophic factor and behavior in an animal model.

Abstract

The mechanism of antidepressant action, at the cellular level, is not clearly understood. It has been reported that chronic antidepressant treatment leads to an up-regulation of brain-derived neurotrophic factor (BDNF) mRNA levels in the hippocampus, and that physical activity (voluntary running) enhances this effect. We wished to investigate whether BDNF… (More)

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