Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus

@article{RussoNeustadt2000PhysicalAA,
  title={Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus},
  author={Amelia A. Russo-Neustadt and Ryan C Beard and Y. Huang and Carl Cotman},
  journal={Neuroscience},
  year={2000},
  volume={101},
  pages={305-312}
}
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EFFECTOF VITAMIN E ON CEREBRALCORTICAL OXIDATIVE STRESS AND BRAIN-DERIVED NEUROTROPHIC FACTOR GENE EXPRESSION INDUCED BY HYPOXIA AND EXERCISE INRATS
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To clarify the changes in BDNF after dif ferent stresses, the expression of BDNF mRNA in the cerebral cortex of Sprague-Dawley rats following chronic exercise is studied by real-time polymerase chain reaction (R T-PCR).
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The relevance of the basic research studies is supported by clinical studies demonstrating that levels of BDNF in brain and plasma of depressed patients is decreased relative to controls and that this effect is reversed by antidepressant treatments.
Neurotrophins and neuronal plasticity in the action of antidepressants and morphine
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It is found that chronic antidepressant treatment increases amount of markers of neuronal plasticity in both hippocampus and in the medial prefrontal cortex, both of which are closely linked to the etiology of major depression.
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The results suggest that the chronic administration of mood stabilizers may produce a neurotrophic effect mediated by the upregulation of BDNF in the rat brain.
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  • Psychology, Biology
    NeuroMolecular Medicine
  • 2007
TLDR
The primary work leading to a neurotrophic hypothesis of depression and antidepressant action is reviewed and the cellular mechanisms and signal transduction pathways that underlie these effects are reviewed.
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This review aims to correlate the features of some CNS disorders to changes in BDNF expression in the brain and finds that this trophic factor is a good candidate for therapeutic treatment of some of CNS disorders.
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References

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Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain
Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus
TLDR
It is demonstrated that BDNF and NT-3 are stress-responsive genes and the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus is raised.
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TLDR
A role of neurotrophic factors in the etiology and treatment of certain psychiatric illnesses is outlined, including electroconvulsive seizure therapy and antidepressant drugs, which increase the expression of brain derived neurotrophic factor and its receptor, trkB, in the brain.
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TLDR
Investigation of chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NGF could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-HT neurotoxin p-chloroamphetamine (PCA).
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TLDR
Data show that the four BDNF promoters allow multiple points ofBDNF mRNA regulation and suggest that the activation of different subtypes of glutamate receptors differentially regulates the expression of BDNF exon-specific mRNAs in the brain.
Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment
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