Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus

@article{RussoNeustadt2000PhysicalAA,
  title={Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus},
  author={Amelia A. Russo-Neustadt and Ryan C Beard and Y. Huang and Carl Cotman},
  journal={Neuroscience},
  year={2000},
  volume={101},
  pages={305-312}
}
A Neurotrophic Model for Stress-Related Mood Disorders
EFFECTOF VITAMIN E ON CEREBRALCORTICAL OXIDATIVE STRESS AND BRAIN-DERIVED NEUROTROPHIC FACTOR GENE EXPRESSION INDUCED BY HYPOXIA AND EXERCISE INRATS
TLDR
To clarify the changes in BDNF after dif ferent stresses, the expression of BDNF mRNA in the cerebral cortex of Sprague-Dawley rats following chronic exercise is studied by real-time polymerase chain reaction (R T-PCR).
Physiology of BDNF: focus on hypothalamic function
Neurotrophic Factors in Etiology and Treatment of Mood Disorders
TLDR
The relevance of the basic research studies is supported by clinical studies demonstrating that levels of BDNF in brain and plasma of depressed patients is decreased relative to controls and that this effect is reversed by antidepressant treatments.
Neurotrophins and neuronal plasticity in the action of antidepressants and morphine
TLDR
It is found that chronic antidepressant treatment increases amount of markers of neuronal plasticity in both hippocampus and in the medial prefrontal cortex, both of which are closely linked to the etiology of major depression.
Chronic lithium treatment increases the expression of brain-derived neurotrophic factor in the rat brain
TLDR
The results suggest that the chronic administration of mood stabilizers may produce a neurotrophic effect mediated by the upregulation of BDNF in the rat brain.
Role of neurotrophic factors in the etiology and treatment of mood disorders
  • R. Duman
  • Psychology, Biology
    NeuroMolecular Medicine
  • 2007
TLDR
The primary work leading to a neurotrophic hypothesis of depression and antidepressant action is reviewed and the cellular mechanisms and signal transduction pathways that underlie these effects are reviewed.
Brain-derived neurotrophic factor as a drug target for CNS disorders
TLDR
This review aims to correlate the features of some CNS disorders to changes in BDNF expression in the brain and finds that this trophic factor is a good candidate for therapeutic treatment of some of CNS disorders.
...
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TLDR
It is demonstrated that BDNF and NT-3 are stress-responsive genes and the possibility that alterations in the expression of these or other growth factors might be important in producing some of the physiological and pathophysiological effects of stress in the hippocampus is raised.
Antidepressant-Like Effect of Brain-derived Neurotrophic Factor (BDNF)
Review : Stress, Antidepressant Treatments, and Neurotrophic Factors: Molecular and Cellular Mechanisms
TLDR
A role of neurotrophic factors in the etiology and treatment of certain psychiatric illnesses is outlined, including electroconvulsive seizure therapy and antidepressant drugs, which increase the expression of brain derived neurotrophic factor and its receptor, trkB, in the brain.
Brain-derived neurotrophic factor promotes the survival and sprouting of serotonergic axons in rat brain
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Investigation of chronic pain parenchymal administration of the neurotrophins brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) or NGF could prevent the severe degenerative loss of serotonergic axons normally caused by the selective 5-HT neurotoxin p-chloroamphetamine (PCA).
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TLDR
Data show that the four BDNF promoters allow multiple points ofBDNF mRNA regulation and suggest that the activation of different subtypes of glutamate receptors differentially regulates the expression of BDNF exon-specific mRNAs in the brain.
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