Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study

  title={Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study},
  author={S. Ahmad and W. Zhao and F. Renstr{\"o}m and A. Rasheed and M. Samuel and Mozzam Zaidi and N. Shah and N. H. Mallick and K. Zaman and M. Ishaq and S. Z. Rasheed and Fazal-ur-Rheman Memon and B. Hanif and M. S. Lakhani and F. Ahmed and S. Kazmi and P. Frossard and P. Franks and D. Saleheen},
  journal={BMC Medical Genetics},
  • S. Ahmad, W. Zhao, +16 authors D. Saleheen
  • Published 2015
  • Medicine
  • BMC Medical Genetics
  • BackgroundMultiple genetic variants have been reliably associated with obesity-related traits in Europeans, but little is known about their associations and interactions with lifestyle factors in South Asians.MethodsIn 16,157 Pakistani adults (8232 controls; 7925 diagnosed with myocardial infarction [MI]) enrolled in the PROMIS Study, we tested whether: a) BMI-associated loci, individually or in aggregate (as a genetic risk score - GRS), are associated with BMI; b) physical activity and smoking… CONTINUE READING
    18 Citations
    Gene Lifestyle Interactions With Relation to Obesity, Cardiometabolic, and Cardiovascular Traits Among South Asians
    • 4
    • PDF
    The importance of gene-environment interactions in human obesity.
    • 70
    Analysis of Positive Selection at Single Nucleotide Polymorphisms Associated with Body Mass Index Does Not Support the "Thrifty Gene" Hypothesis.
    • 22
    • Highly Influenced
    Epidemiologic studies targeting primary cardiovascular disease prevention in South Asia
    • 1
    • Highly Influenced
    • PDF
    A high-fat diet alters genome-wide DNA methylation and gene expression in SM/J mice
    • 20
    Gene-nutrient interactions and susceptibility to human obesity
    • 12


    Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies.
    • 193
    • PDF
    Combined Analyses of 20 Common Obesity Susceptibility Variants
    • 51
    • PDF
    General and abdominal adiposity and risk of death in Europe.
    • 1,137
    • PDF