Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review

@article{Lacorte2016PhysicalAA,
  title={Physical activity, and physical activity related to sports, leisure and occupational activity as risk factors for ALS: A systematic review},
  author={Eleonora Lacorte and Luigina Ferrigno and Emanuele Leoncini and Massimo Corbo and Stefania Boccia and Nicola Vanacore},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2016},
  volume={66},
  pages={61-79}
}

Figures and Tables from this paper

Life Course of Physical Activity and Risk and Prognosis of Amyotrophic Lateral Sclerosis in a German ALS Registry

A strong nonlinear association of current and prediagnostic PA level and survival in ALS cases with the best survival with moderate PA is found, suggesting PA intensity may be a disease-modifying factor with an unfavorable outcome in sedentary and hyperactive behavior.

Contact Sports as a Risk Factor for Amyotrophic Lateral Sclerosis: A Systematic Review

It is suggested that increased susceptibility to ALS is significantly and independently associated with professional sports and sports prone to repetitive concussive head and cervical spinal trauma, further increasing this association to ALS.

Multicentre, cross-cultural, population-based, case–control study of physical activity as risk factor for amyotrophic lateral sclerosis

New class I evidence for a positive association between PA and risk of ALS is provided in a large multicentre study using harmonised methodology to objectively quantify PA levels, with some suggestions for population differences.

A systematic review on the risk of neurodegenerative diseases and neurocognitive disorders in professional and varsity athletes

The aim of this systematic review (SR) was to gather all available epidemiological evidence on former participation in any type of sport, at a professional and varsity level, as a potential risk

Amyotrophic Lateral Sclerosis and Occupational Exposures: A Systematic Literature Review and Meta-Analyses

Meta-analyses based only on epidemiologic publications of good scientific quality show that the risk of ALS is statistically significantly elevated for occupational exposures to excessive physical work, chemicals, metals, metals (especially lead), and possibly also to electromagnetic fields and health care work.

Clinical and Lifestyle Factors and Risk of Amyotrophic Lateral Sclerosis: A Population-Based Case-Control Study

A population-based case-control study in four provinces from both Northern and Southern Italy suggests a potential etiologic role a number of clinical and lifestyle factors with ALS risk, however, caution is needed due to some study limitations.

History of vigorous leisure-time physical activity and early onset amyotrophic lateral sclerosis (ALS), data from the national ALS registry: 2010–2018

Patients with ALS who had a history of VPA before age 35, were significantly more likely to be diagnosed with ALS before age 60 compared to patients withALS who never engaged vigorously.

Finding diseases associated with amyotrophic lateral sclerosis: a total population-based case–control study

The hypothesis that diseases developing prior to ALS diagnoses are hypermetabolic disorders may have a beneficial effect on ALS incidence is supported and defective energy metabolism may play a role in ALS pathogenesis.
...

References

SHOWING 1-10 OF 101 REFERENCES

Epidemiological evidence that physical activity is not a risk factor for ALS

A literature review of epidemiological studies was conducted according to the Meta-analysis of Observational Studies in Epidemiology guidelines, establishing (level A) that PA is not a risk factor for ALS.

Lifetime physical activity and the risk of amyotrophic lateral sclerosis

An increased risk of ALS with higher levels of leisure time physical activity was found and the lack of association with occupational physical activity and the absence of a dose–response relationship strengthen the hypothesis that not increased physical activity per se but rather a genetic profile or lifestyle promoting physical fitness increases ALS susceptibility.

Physical activity and the association with sporadic ALS

Smoking and alcohol use were independently associated with ALS, and no significant association with occupational or leisure time physical activity was found, which was in agreement with most studies with the highest level of evidence.

What we truly know about occupation as a risk factor for ALS: A critical and systematic review

  • N. SutedjaK. Fischer L. H. van den Berg
  • Medicine, Psychology
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
A systematic review of the literature on occupation as a potential determinant of ALS was performed according to the MOOSE guidelines, revealing several candidate occupations: veterinarians and other health workers, athletes, hairdressers, power-production plant, electrical and military workers.

Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study.

A history of physical activity has little, if any, effect on the risk of ALS.

Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence

  • Ceryl A HarwoodC. McdermottP. Shaw
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2009
The existing literature regarding physical activity as a risk factor for MND and the potential biological and genetic plausibility for this association are reviewed.

Physical fitness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age

Physical fitness, but not muscle strength, is a risk factor for death at early age in ALS, and this may indicate that a common factor underlies both fitness (W/kg) and risk of ALS.

Physical activity, trauma, and ALS: a case‐control study

Severe head, neck, and back injury and frequency of sweating both in work and leisure activity showed a strong association with ALS, and possible explanations include trauma and vigorous exercise precipitating ALS.

Amyotrophic lateral sclerosis, physical exercise, trauma and sports: Results of a population-based pilot case-control study

  • E. BeghiG. Logroscino B. Traynor
  • Medicine
    Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
  • 2010
It is concluded that ALS is associated with physical exercise but not with traumatic events, compared to the general population.
...