Physical Stability of Ethyl Diatrizoate Nanocrystalline Suspension in Steam Sterilization

Abstract

Purpose. To study the effects of formulation variables on the physical stability of a submicron crystal (nanocrystal) suspension under steam sterilization conditions. Methods. Suspensions of ethyl diatrizoate nanocrystals were prepared by wet milling in the presence of the surfactant poloxamine 908. Particle size distribution and zeta potential were… (More)
DOI: 10.1023/A:1018883431970

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