Physical Properties of Intact Proteins May Predict Allergenicity or Lack Thereof

@inproceedings{Singh2009PhysicalPO,
  title={Physical Properties of Intact Proteins May Predict Allergenicity or Lack Thereof},
  author={Suchita Singh and Bhupesh Taneja and Sundeep Salvi and Anurag Agrawal},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Predicting the allergenicity of proteins is challenging. We considered the possibility that the properties of the intact protein that may alter the likelihood of being taken up by antigen presenting cells, may be useful adjuncts in predicting allergens and non-allergens in silico. It has been shown that negatively charged acidic proteins are preferentially processed by dendritic cells. METHODOLOGY Datasets (aeroallergen, food-allergen and non-allergen) for in-silico study were… CONTINUE READING

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