Physical Network Models

  title={Physical Network Models},
  author={Chen-Hsiang Yeang and Trey Ideker and Tommi S. Jaakkola},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  volume={11 2-3},
We develop a new framework for inferring models of transcriptional regulation. The models, which we call physical network models, are annotated molecular interaction graphs. The attributes in the model correspond to verifiable properties of the underlying biological system such as the existence of protein-protein and protein-DNA interactions, the directionality of signal transduction in protein-protein interactions, as well as signs of the immediate effects of these interactions. Possible… CONTINUE READING