Physical-Chemical Stability , and Release Studies of Four Alcohol-Free Spironolactone Suspensions for Use in Pediatrics

@inproceedings{Bernal2014PhysicalChemicalS,
  title={Physical-Chemical Stability , and Release Studies of Four Alcohol-Free Spironolactone Suspensions for Use in Pediatrics},
  author={Nora Provenza Bernal and Ana Cristina Calpena and Mireia Mallandrich and Adolfina Ruiz and Beatriz Clares},
  year={2014}
}
Dissolution studies have become of great significance because, in most cases, drug dissolution is the rate-limiting step in the absorption process. As occurs with solid oral dosage forms, heterogeneous dispersed systems (suspensions) could also have some problems with their in vitro dissolution. The objective of this study was to evaluate the influence of excipients on the release of spironolactone from four alcohol-free suspensions (pharmaceutical compounding) of spironolactone 5 mg/mL… CONTINUE READING