Physical Characterization of Pharmaceutical Solids

  title={Physical Characterization of Pharmaceutical Solids},
  author={Harry G. Brittain and Susan J. Bogdanowich and David E. Bugay and Joseph Devincentis and Geoff Lewen and Ann Newman},
  journal={Pharmaceutical Research},
A general review of the methods available for the physical characterization of pharmaceutical solids is presented. The techniques are classified as being on the molecular level (properties capable of being detected in an ensemble of individual molecules), the particulate level (properties which can be detected through the analysis of an ensemble of particles), and the bulk level (properties which can be measured only using a relatively large amount of material). The molecular-level properties… 

Particle and Powder Bed Properties

Micromeritics is the study of the science and technology of small particles (1); this includes the characterization of important properties such as particle size, size distribution, shape, and many

Particle Size Analysis in Pharmaceutics: Principles, Methods and Applications

This review offers an in-depth discussion on particle size analysis pertaining to specific pharmaceutical applications and regulatory aspects, fundamental principles and terminology, instrumentation types, data presentation and interpretation, in-line and process analytical technology.

An overview of recent studies on the analysis of pharmaceutical polymorphs.

Characterisation of salts of drug substances

The properties of the solid-state of drug substances are critical factors that determine the choice of an appropriate salt form for the development of the pharmaceutical formulation. The most

Influence of Solvents on the Crystal Habit and Properties of Rofecoxib

In the present investigation of a total of four rofecoxib crystals were prepared successfully. Most pharmaceutical powders have crystals and used in the design of dosage forms, crystalline materials

Physical characterization of component particles included in dry powder inhalers. I. Strategy review and static characteristics

The performance of dry powder aerosols for the delivery of drugs to the lungs has been studied extensively in the last decade. The focus for different research groups has been on aspects of the

Physico-chemical aspects of lactose for inhalation.

The micro and nano scale characterization and identification of tablet formulations

The aim of this project was to characterize the surface properties of materials used in tablet formulations with sub-micron resolution by the techniques of Atomic Force Microscopy (AFM), Scanning



Applications of thermal analysis in the pharmaceutical industry.

  • D. Giron
  • Materials Science
    Journal of pharmaceutical and biomedical analysis
  • 1986

Overcoming Particle Segregation in the Pharmaceutical and Cosmetics Industries

AbstractSegregation (separation) of particles in mixtures is a common problem in many industries. In the pharmaceutical industry such segregation is often of major concern when handling direct

Modern methods of particle size analysis

Commercial Instrumentation for Particle Size Analysis. The Application of Particle Characterization Methods to Submicron Dispersions and Emulsions. Particle Size Using Photon Correlation

Handbook of Pharmaceutical Excipients

The Handbook of Pharmaceutical Excipients is internationally recognised as the authoritative source of information on pharmaceutical excipients giving a comprehensive guide to uses, properties and

Handbook of Powder Science & Technology

Particle size characterization. Particle shape characterization. Structural properties of packings of particles. Fundamental and rheological properties of powders. Vibration of fine powders and its

Powder surface area and porosity

1 Theoretical.- 1 Introduction.- 2 Gas adsorption.- 3 Adsorption isotherms.- 4 Langmuir and BET theories (kinetic isotherms).- 5 The single point BET method.- 6 Adsorbate cross-sectional areas.- 7

Fourier Transform Infrared Spectroscopy

Typically, lignins are characterized by IR spectroscopy in the solid state. The examination of lignins in solution has long been a domain of UV and NMR spectroscopy. However, with the advent of the

Conformation‐dependent 13C chemical shifts: A new means of conformational characterization as obtained by high‐resolution solid‐state 13C NMR

A survey of recent high‐resolution solid‐state 13C NMR studies is given to illustrate how and to what extent 13C chemical shifts of a variety of molecular systems are displaced upon conformational

The Adsorption of Gases and Vapours

DR. BRUNAUER has given in this, the first part of a work designed to cover all the phenomena of adsorption of gases on solids, by far the most thorough and comprehensive account that has yet