Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis

@article{Berry2012Phylotypelevel1R,
  title={Phylotype-level 16S rRNA analysis reveals new bacterial indicators of health state in acute murine colitis},
  author={David Berry and Clarissa Schwab and Gabriel Milinovich and Jochen Reichert and Karim Ben Mahfoudh and Thomas Decker and Marion Engel and Brigitte Hai and Eva Hainzl and S. Heider and Lukas Kenner and Mathias Mueller and Isabella Rauch and Birgit Strobl and Michael Wagner and Christa Schleper and Tim Urich and Alexander Loy},
  journal={The ISME Journal},
  year={2012},
  volume={6},
  pages={2091-2106}
}
Human inflammatory bowel disease and experimental colitis models in mice are associated with shifts in intestinal microbiota composition, but it is unclear at what taxonomic/phylogenetic level such microbiota dynamics can be indicative for health or disease. Here, we report that dextran sodium sulfate (DSS)-induced colitis is accompanied by major shifts in the composition and function of the intestinal microbiota of STAT1−/− and wild-type mice, as determined by 454 pyrosequencing of bacterial… CONTINUE READING

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