Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.

@article{Mbius2008PhylogenyOP,
  title={Phylogeny of proteolipid proteins: divergence, constraints, and the evolution of novel functions in myelination and neuroprotection.},
  author={Wiebke M{\"o}bius and Julia Patzig and Klaus-Armin Nave and Hauke B Werner},
  journal={Neuron glia biology},
  year={2008},
  volume={4 2},
  pages={111-27}
}
The protein composition of myelin in the central nervous system (CNS) has changed at the evolutionary transition from fish to tetrapods, when a lipid-associated transmembrane-tetraspan (proteolipid protein, PLP) replaced an adhesion protein of the immunoglobulin superfamily (P0) as the most abundant constituent. Here, we review major steps of proteolipid evolution. Three paralog proteolipids (PLP/DM20/DMalpha, M6B/DMgamma and the neuronal glycoprotein M6A/DMbeta) exist in vertebrates from… CONTINUE READING

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Three paralog proteolipids ( PLP / DM20/DMalpha , M6B / DMgamma and the neuronal glycoprotein M6A / DMbeta ) exist in vertebrates from cartilaginous fish to mammals , and one ( M6/CG7540 ) can be traced in invertebrate bilaterians including the planktonic copepod Calanus finmarchicus that possess a functional myelin equivalent .
Three paralog proteolipids ( PLP / DM20/DMalpha , M6B / DMgamma and the neuronal glycoprotein M6A / DMbeta ) exist in vertebrates from cartilaginous fish to mammals , and one ( M6/CG7540 ) can be traced in invertebrate bilaterians including the planktonic copepod Calanus finmarchicus that possess a functional myelin equivalent .
PLP emerged at the root of tetrapods by the acquisition of an enlarged cytoplasmic loop in the evolutionary older DMalpha / DM20 .
PLP1 geneGene encodes gene productPLP1 protein, human
PLP emerged at the root of tetrapods by the acquisition of an enlarged cytoplasmic loop in the evolutionary older DMalpha / DM20 .
PLP emerged at the root of tetrapods by the acquisition of an enlarged cytoplasmic loop in the evolutionary older DMalpha / DM20 .
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