Phylogeny of Shiga Toxin-Producing Escherichia coli O157 Isolated from Cattle and Clinically Ill Humans

@inproceedings{Bono2012PhylogenyOS,
  title={Phylogeny of Shiga Toxin-Producing Escherichia coli O157 Isolated from Cattle and Clinically Ill Humans},
  author={James L Bono and Timothy L Smith and James E. Keen and Gregory P. Harhay and Tara G. McDaneld and Robert E. Mandrell and Woo Kyung Jung and Thomas E Besser and Peter Gerner-Smidt and Martina Bielaszewska and Helge Karch and Michael L. Clawson},
  booktitle={Molecular biology and evolution},
  year={2012}
}
Cattle are a major reservoir for Shiga toxin-producing Escherichia coli O157 (STEC O157) and harbor multiple genetic subtypes that do not all associate with human disease. STEC O157 evolved from an E. coli O55:H7 progenitor; however, a lack of genome sequence has hindered investigations on the divergence of human- and/or cattle-associated subtypes. Our goals were to 1) identify nucleotide polymorphisms for STEC O157 genetic subtype detection, 2) determine the phylogeny of STEC O157 genetic… CONTINUE READING
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