Phylogeny based discovery of regulatory elements

@article{Gertz2006PhylogenyBD,
  title={Phylogeny based discovery of regulatory elements},
  author={Jason Gertz and Justin C. Fay and Barak A. Cohen},
  journal={BMC Bioinformatics},
  year={2006},
  volume={7},
  pages={266 - 266}
}
Algorithms that locate evolutionarily conserved sequences have become powerful tools for finding functional DNA elements, including transcription factor binding sites; however, most methods do not take advantage of an explicit model for the constrained evolution of functional DNA sequences. We developed a probabilistic framework that combines an HKY85 model, which assigns probabilities to different base substitutions between species, and weight matrix models of transcription factor binding… CONTINUE READING

Topics

Statistics

050100'07'08'09'10'11'12'13'14'15'16'17'18
Citations per Year

139 Citations

Semantic Scholar estimates that this publication has 139 citations based on the available data.

See our FAQ for additional information.