Phylogenomics of Cas4 family nucleases

  title={Phylogenomics of Cas4 family nucleases},
  author={Sanjarbek Hudaiberdiev and Sergey A Shmakov and Yuri I. Wolf and Michael P Terns and Kira S. Makarova and Eugene V. Koonin},
  booktitle={BMC Evolutionary Biology},
The Cas4 family endonuclease is a component of the adaptation module in many variants of CRISPR-Cas adaptive immunity systems. Unlike most of the other Cas proteins, Cas4 is often encoded outside CRISPR-cas loci (solo-Cas4) and is also found in mobile genetic elements (MGE-Cas4). As part of our ongoing investigation of CRISPR-Cas evolution, we explored the phylogenomics of the Cas4 family. About 90% of the archaeal genomes encode Cas4 compared to only about 20% of the bacterial genomes. Many… CONTINUE READING
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