Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes

@article{Kroken2003PhylogenomicAO,
  title={Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes},
  author={S. Kroken and N. L. Glass and John W. Taylor and O. Yoder and B. Turgeon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2003},
  volume={100},
  pages={15670 - 15675}
}
  • S. Kroken, N. L. Glass, +2 authors B. Turgeon
  • Published 2003
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
Fungal type I polyketides (PKs) are synthesized by PK synthases (PKSs) and include well known secondary metabolites such as the anticholesterol drug lovastatin and the potent natural carcinogen aflatoxin. Other type I PKs are known to be virulence factors for some plant pathogens and pigments such as melanin. In this study, a phylogenomic approach was used to investigate the origin and diversity of fungal genes encoding putative PKSs that are predicted to synthesize type I PKs. The resulting… Expand
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