Phylogenetic evidence for the early evolution of microcystin synthesis.

  title={Phylogenetic evidence for the early evolution of microcystin synthesis.},
  author={Anne Rantala and David P Fewer and Michael Hisbergues and Leo Rouhiainen and Jaana Vaitomaa and Thomas B{\"o}rner and Kaarina Sivonen},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={101 2},
Cyanobacteria are a prolific source of secondary metabolites, including compounds with toxic and enzyme-inhibiting activities. Microcystins and nodularins are the end products of a secondary metabolic pathway comprised of mixed polyketide synthases and nonribosomal peptide synthetases. Both peptides are potent natural toxins produced by distantly related genera of cyanobacteria. Horizontal gene transfer is thought to play a role in the sporadic distribution of microcystin producers among… CONTINUE READING
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