Phylogenetic diversification of immunoglobulin genes and the antibody repertoire.

@article{Litman1993PhylogeneticDO,
  title={Phylogenetic diversification of immunoglobulin genes and the antibody repertoire.},
  author={Gary W. Litman and Jonathan P. Rast and Michael J. Shamblott and Robert N. Haire and M. P. M. van der Hulst and W Roess and Ronda T. Litman and K R Hinds-Frey and A Zilch and Chris T Amemiya},
  journal={Molecular biology and evolution},
  year={1993},
  volume={10 1},
  pages={60-72}
}
Immunoglobulins are encoded by a large multigene system that undergoes somatic rearrangement and additional genetic change during the development of immunoglobulin-producing cells. Inducible antibody and antibody-like responses are found in all vertebrates. However, immunoglobulin possessing disulfide-bonded heavy and light chains and domain-type organization has been described only in representatives of the jawed vertebrates. High degrees of nucleotide and predicted amino acid sequence… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 35 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 28 references

Isolation of a hagfish gene that encodes a complement component

  • Ishiguro, K Kobayashi, M Suzuki, K Titani, S Tomonaga, Y Kurosawa
  • EMBO J
  • 1992

The complete nucleotide sequence of an immunoglobulin heavy chain gene and analysis of immunoglobulin gene organization in primitive teleost species Early evolution of immunoglobulin genes

  • Amemiya, G W Litman
  • Proc. Natl. Acad. Sci. USA
  • 1990

Similar Papers

Loading similar papers…