Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system.

  title={Phylogenetic distribution of aromatase and other androgen-converting enzymes in the central nervous system.},
  author={G. Callard and Z. Petro and K. Ryan},
  volume={103 6},
Metabolism of [3H]androstenedione was studied in brain tissue homogenates of opossum, bird, snake, sea turtle, urodele amphibian, teleost, shark, skate, hagfish, and lobster. Estrone, 17 beta-estradiol, or 17 alpha-estradiol was formed by central neural tissues of all species, with the exception of the opossum, hagfish, and lobster. Aromatase activity was concentrated in the forebrain, although some estrogen was synthesized by mid- or hindbrain homogenates of two lower vertebrates (teleost and… Expand
Aromatase and 5α-reductase in the teleost brain, spinal cord, and pituitary gland ☆
High levels of aromatase in the neuroendocrine tissues of teleosts recommend them as animal models for further studying the enzyme, its regulation, and its role in governing androgen-dependent responses in central targets. Expand
Aromatization and 5 alpha-reduction in brain and nonneural tissues of a cyclostome, Petromyzon marinus.
The presence of 5α-reductase in cyclostome brain is consistent with the widespread phylogenetic distribution of this enzyme although the occurrence of central aromatase activity in Agnatha has yet to be demonstrated. Expand
Estrogen synthesis in vitro and in vivo in the brain of a marine teleost (Myoxocephalus).
The presence of relatively large amounts of estrogen in the sculpin pituitary following perfusion with radiolabeled androgen suggests that, at this level of phylogeny, the brain may regulatepituitary function by supplying estrogen directly, or the pitsuitary itself is capable of aromatization. Expand
Aromatase activity in marsupial brain, ovaries, and adrenals.
This study provides the first definitive evidence for synthesis of conventional eutherian estrogens in Metatheria by methylation and crystallization to constant specific activity. Expand
Cyp19a1 (Aromatase) Expression in the Xenopus Brain at Different Developmental Stages
Investigation of the precise neuroanatomical distribution of cyp19a1 mRNA during brain development in Xenopus laevis suggests that, similar to that found in other tetrapods, aromatase in the brain of amphibians is found in post‐mitotic neurones and not in radial glia as reported in teleosts. Expand
A comparison of aromatase, 5α‐, and 5β‐ reductase activities in the brain and pituitary of male and female quail (C. c. japonica)
The first definitive identification of aromatase in quail pituitary is made and a complex of androgen-metabolizing enzymes controls the neuroanatomic (spatial) distribution of active hormone in neuroendocrine tissues and that quantitative differences between males and females may account for sex differences in behavior are suggested. Expand
Androgen metabolism in the brain of the green anole lizard (Anolis carolinensis).
  • J. Wade
  • Biology, Medicine
  • General and comparative endocrinology
  • 1997
Differences exist among brain regions, such that aromatase activity is higher in preoptic area/hypothalamic dissections, whereas 5 alpha-reductase is much more active in the brain stem, and variations in regional enzyme activity may influence steroid hormone regulation of specific sexual behaviors in male and female anoles. Expand
Aromatase distribution and regulation in fish
Aromatase mRNA expression studies revealed that P 450aromA and P450aromB are preferentially, but not exclusively, expressed in the gonads and brain, respectively, suggesting local actions of estrogens in several peripheral targets. Expand
Conversion of Androgen to Estrogen and Other Steroids in the Vertebrate Brain
Comparative studies together with autoradiographic, physiological, and behavioral data in mammals and selected nonmammalian species support the view that metabolism in situ is an important component of androgen action and a general characteristic of the vertebrate brain. Expand
Aromatase in the brain of teleost fish: Expression, regulation and putative functions
In situ hybridization, immunohistochemistry and expression of GFP in transgenic tg(cyp19a1b-GFP) fish demonstrate that aromatase B is only expressed in radial glial cells (RGC) of adult fish, suggesting that it could be part of the mechanisms authorizing the maintenance of a high proliferative activity in the brain of fish. Expand


Androgen metabolism in the brain and non-neural tissues of the bullfrog Rana catesbeiana.
The experiments reported here indicate that the conversion of androgen to estrogen and other neutral metabolites by the brain is a primitive tetrapod characteristic and suggest that metabolism is an integral component of brain-steroid interactions which has been conserved during the evolution of vertebrates. Expand
The archistriatum of the pigeon: organization of afferent and efferent connections.
The results obtained suggest a subdivision of the archistriatum into 4 major regions: the anterior, intermedium, posterior (with a postero-ventral portion) and mediale, which give rise to descending pathways terminating in the medial and lateral hypothalamus, and may therefore be comparable to the mammalian amygdala. Expand
Olfactory bulb projections in the bullfrog Rana catesbeiana
The projections of the accessory and main olfactory bulbs of the bullfrog are described as part of a long term analysis of the morphological differences in amphibian and reptilian telencephalons.Expand
1. The reptilian hemisphere has been studied mainly from a morphological point of view and for the most part with techniques which are capable of providing no more than a preliminary survey of theExpand
The Life of Vertebrates
The life of vertebrates is studied in detail in order to provide a fuller picture of the complex web of connective tissue in the animal kingdom. Expand
The vertebrate body
This ebooks is under topic such as comparative embryology: the vertebrates body on in situ attrition and vertebrate body part profiles. Expand
The chicken telencephalon, diencephalon and mesencephalon in stereotaxic coordinates