Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays.

@article{Tierney2004PhylogeneticCO,
  title={Phylogenetic conservation of disulfide-linked, dimeric acetylcholine receptor pentamers in southern ocean electric rays.},
  author={M. Louise Tierney and Kenneth E Osborn and Peter John Milburn and Michael H B Stowell and Susan M. Howitt},
  journal={The Journal of experimental biology},
  year={2004},
  volume={207 Pt 20},
  pages={3581-90}
}
Intact acetylcholine receptors have been purified on a novel affinity resin from three electric fish endemic to Australian waters. Their binding properties and morphology are compared with those of their northern hemisphere homolog, Torpedo marmorata. All four exhibit apparent dissociation constants, Kd, in the nanomolar range for the snake neurotoxin alpha-bungarotoxin and have a distinctive rosette-like appearance when viewed in negative stain under the electron microscope. Furthermore, these… CONTINUE READING