Phylogenetic approach to recover integration dates of latent HIV sequences within-host

  title={Phylogenetic approach to recover integration dates of latent HIV sequences within-host},
  author={Bradley R. Jones and Natalie Nicole Kinloch and Joshua Horacsek and Bruce Ganase and M. W. Harris and PAUL. Harrigan and Richard B. Jones and Mark A Brockman and Jeffrey B. Joy and Art F. Y. Poon and Zabrina L. Brumme},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
Given that HIV evolution and latent reservoir establishment occur continually within-host, and that latently infected cells can persist long-term, the HIV reservoir should comprise a genetically heterogeneous archive recapitulating within-host HIV evolution. However, this has yet to be conclusively demonstrated, in part due to the challenges of reconstructing within-host reservoir establishment dynamics over long timescales. We developed a phylogenetic framework to reconstruct the integration… CONTINUE READING

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