Phylogenetic and structural analyses of MMTV LTR ORF sequences of exogenous and endogenous origins.

@article{BrandtCarlson1993PhylogeneticAS,
  title={Phylogenetic and structural analyses of MMTV LTR ORF sequences of exogenous and endogenous origins.},
  author={C Brandt-Carlson and Janet S Butel and David Wheeler},
  journal={Virology},
  year={1993},
  volume={193 1},
  pages={171-85}
}
The long terminal repeat (LTR) of mouse mammary tumor virus (MMTV) harbors an open reading frame (ORF) that encodes a glycoprotein and is present in all exogenous and endogenous MMTV proviruses. The ORF protein has been reported to interact with the immune system of mice to cause deletion of specific V beta-bearing subsets of T cells. Twenty-two MMTV LTR ORF sequences were analyzed. Although highly conserved, the MMTV ORF sequences are not identical, with approximately 35% of the total… CONTINUE READING

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