Phylogenetic and Functional Classification of Mitogen- and Stress-Activated Protein Kinases

  title={Phylogenetic and Functional Classification of Mitogen- and Stress-Activated Protein Kinases},
  author={Dietmar K{\"u}ltz},
  journal={Journal of Molecular Evolution},
  • D. Kültz
  • Published 1 May 1998
  • Biology
  • Journal of Molecular Evolution
Abstract. All currently sequenced stress-activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and other mitogen-activated protein kinases (MAPKs) were analyzed by sequence alignment, phylogenetic tree construction, and three-dimensional structure modeling in order to classify members of the MAPK family. Based on this analysis the MAPK family was divided into three subgroups (SAPKs, ERKs, and MAPK3) that consist of at least nine subfamilies. Members of a given… 

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