Phylogenetic analysis of the cadherin superfamily.

  title={Phylogenetic analysis of the cadherin superfamily.},
  author={Y Pouliot},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={14 11},
  • Y Pouliot
  • Published 1992 in
    BioEssays : news and reviews in molecular…
Cadherins are a multigene family of proteins which mediate homophilic calcium-dependent cell adhesion and are thought to play an important role in morphogenesis by mediating specific intercellular adhesion. Different lines of experimental evidence have recently indicated that the site responsible for mediating adhesive interactions is localized to the first extracellular domain of cadherin. Based upon an analysis of the sequence of this domain, I show that cadherins can be classified into three… CONTINUE READING