Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes.

@article{Louwagie1993PhylogeneticAO,
  title={Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes.},
  author={Joost Louwagie and Francine E. McCutchan and Martine Peeters and Timothy P Brennan and Eric Sanders-Buell and Graham Eddy and Guido van der Groen and Katrien Fransen and G. M. Gershy-Damet and R Deleys},
  journal={AIDS},
  year={1993},
  volume={7 6},
  pages={769-80}
}
OBJECTIVE To determine the extent of genetic variation among internationally collected HIV-1 isolates, to analyse phylogenetic relationships and the geographic distribution of different variants. DESIGN Phylogenetic comparison of 70 HIV-1 isolates collected in 15 countries on four continents. METHODS To sequence the complete gag genome of HIV-1 isolates, build multiple sequence alignments and construct phylogenetic trees using distance matrix methods and maximum parsimony algorithms… CONTINUE READING