Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes.

@article{Louwagie1993PhylogeneticAO,
  title={Phylogenetic analysis of gag genes from 70 international HIV-1 isolates provides evidence for multiple genotypes.},
  author={Joost Louwagie and Francine E. McCutchan and Monika Peeters and Terrance P. Brennan and Eric Sanders-Buell and Gerald A. Eddy and Guido van der Groen and Katrien Fransen and Guy Gershy-Damet and Robert Deleys},
  journal={AIDS},
  year={1993},
  volume={7 6},
  pages={
          769-80
        }
}
OBJECTIVE To determine the extent of genetic variation among internationally collected HIV-1 isolates, to analyse phylogenetic relationships and the geographic distribution of different variants. DESIGN Phylogenetic comparison of 70 HIV-1 isolates collected in 15 countries on four continents. METHODS To sequence the complete gag genome of HIV-1 isolates, build multiple sequence alignments and construct phylogenetic trees using distance matrix methods and maximum parsimony algorithms… CONTINUE READING
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