Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers.

  title={Phylogenetic analysis of Sec7-domain-containing Arf nucleotide exchangers.},
  author={Randal Cox and Roberta J. Mason-Gamer and Catherine L Jackson and Nava Segev},
  journal={Molecular biology of the cell},
  volume={15 4},
The eukaryotic family of ADP-ribosylation factor (Arf) GTPases plays a key role in the regulation of protein trafficking, and guanine-nucleotide exchange is crucial for Arf function. Exchange is stimulated by members of another family of proteins characterized by a 200-amino acid Sec7 domain, which alone is sufficient to catalyze exchange on Arf. Here, we analyzed the phylogeny of Sec7-domain-containing proteins in seven model organisms, representing fungi, plants, and animals. The phylogenetic… CONTINUE READING
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