Phylogenetic Analysis of Eukaryotic Thiolases Suggests Multiple Proteobacterial Origins

@article{Peret2004PhylogeneticAO,
  title={Phylogenetic Analysis of Eukaryotic Thiolases Suggests Multiple Proteobacterial Origins},
  author={Juli Peret{\'o} and Purificaci{\'o}n L{\'o}pez-Garc{\'i}a and David Costa Moreira},
  journal={Journal of Molecular Evolution},
  year={2004},
  volume={61},
  pages={65-74}
}
Eukaryotic thiolases are essential enzymes located in three different compartments (peroxisome, mitochondrion, and cytosol) that can display catabolic or anabolic functions. They are responsible for the thiolytic cleavage of oxidized acyl-CoA (thiolase I; EC 2.3.1.16) and the synthesis or degradation of acetoacetyl-CoA (thiolase II; EC 2.3.1.9). Phylogenetic analysis of eukaryotic thiolase sequences showed that they form six distinct clusters, one of them highly divergent, which are in good… CONTINUE READING

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