Phylogenetic Analysis and in Silico Characterization of the GARS-AIRS-GART Gene which Codes for a tri-Functional Enzyme Protein Involved in de novo Purine Biosynthesis

@article{Banerjee2009PhylogeneticAA,
  title={Phylogenetic Analysis and in Silico Characterization of the GARS-AIRS-GART Gene which Codes for a tri-Functional Enzyme Protein Involved in de novo Purine Biosynthesis},
  author={D. Banerjee and K. Nandagopal},
  journal={Molecular Biotechnology},
  year={2009},
  volume={42},
  pages={306-319}
}
  • D. Banerjee, K. Nandagopal
  • Published 2009
  • Biology, Medicine
  • Molecular Biotechnology
  • Human GARS-AIRS-GART encodes a fused tri-functional enzyme protein involved in de novo purine biosynthesis, aberrant function being implicated in Down syndrome and Leukemia. We performed phylogenetic analysis to discern evolutionary relationships and in silico characterization to identify elements potentially important for gene regulation. We report that murine, bovine and chimpanzee sequences are the nearest neighbors of human GARS-AIRS-GART and that endo-duplication of the AIRS protein is… CONTINUE READING
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