Phylogenetic Analysis Supports a Link between DUF1220 Domain Number and Primate Brain Expansion

Abstract

The expansion of DUF1220 domain copy number during human evolution is a dramatic example of rapid and repeated domain duplication. Although patterns of expression, homology, and disease associations suggest a role in cortical development, this hypothesis has not been robustly tested using phylogenetic methods. Here, we estimate DUF1220 domain counts across… (More)
DOI: 10.1093/gbe/evv122

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