PhyloGenie: automated phylome generation and analysis.

  title={PhyloGenie: automated phylome generation and analysis.},
  author={Tancred Frickey and Andrei N. Lupas},
  journal={Nucleic acids research},
  volume={32 17},
Phylogenetic reconstruction is the method of choice to determine the homologous relationships between sequences. Difficulties in producing high-quality alignments, which are the basis of good trees, and in automating the analysis of trees have unfortunately limited the use of phylogenetic reconstruction methods to individual genes or gene families. Due to the large number of sequences involved, phylogenetic analyses of proteomes preclude manual steps and therefore require a high degree of… CONTINUE READING
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