Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors.

@article{Pierre2000PhylloxinAN,
  title={Phylloxin, a novel peptide antibiotic of the dermaseptin family of antimicrobial/opioid peptide precursors.},
  author={T N Pierre and A A Seon and Mohamed Amiche and Pierre Nicolas},
  journal={European journal of biochemistry},
  year={2000},
  volume={267 2},
  pages={370-8}
}
A novel family of peptide precursors that have very similar N-terminal preprosequences followed by markedly different C-terminal domains has been identified in the skin of hylid frogs belonging to the genus Phyllomedusinae. Biologically active peptides derived from the variable domains include the dermaseptins, 28-34-residue peptides that have a broad-spectrum microbicidal activity, and dermorphin and the deltorphins, D-amino acid containing heptapeptides that are very potent agonists for the… CONTINUE READING

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