Phyllanthus emblica L . extract activates Nrf 2 signalling pathway in HepG 2 cells

  title={Phyllanthus emblica L . extract activates Nrf 2 signalling pathway in HepG 2 cells},
  author={Fei Wang and Hongying Wang},
To investigate the effects of Extracellular signal-Regulated Kinase (ERK), p38 mitogen-Activated Protein Kinase (p38MAPK) and other kinase pathways on the activation of Nuclear related factor 2 (Nrf2) signalling pathway by Phyllanthus emblica L. extract (PET). After pre-treatment with different protease inhibitors for 2 h, cells were interfered with Phyllanthus emblica L. extract for 24 h. mRNA expressions of Nrf2 and downstream target genes HO-1, NQO1, P-gp, MRP2 were detected by RT-PCR… CONTINUE READING


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