Phyletic Profiling with Cliques of Orthologs Is Enhanced by Signatures of Paralogy Relationships

@inproceedings{Skunca2013PhyleticPW,
  title={Phyletic Profiling with Cliques of Orthologs Is Enhanced by Signatures of Paralogy Relationships},
  author={Nives Skunca and Matko Bosnjak and Anita Kri{\vs}ko and Pance Panov and Saso Dzeroski and Tomislav Smuc and Fran Supek},
  booktitle={PLoS Computational Biology},
  year={2013}
}
New microbial genomes are sequenced at a high pace, allowing insight into the genetics of not only cultured microbes, but a wide range of metagenomic collections such as the human microbiome. To understand the deluge of genomic data we face, computational approaches for gene functional annotation are invaluable. We introduce a novel model for computational annotation that refines two established concepts: annotation based on homology and annotation based on phyletic profiling. The phyletic… CONTINUE READING