Phthalates might interfere with testicular function by reducing testosterone and insulin-like factor 3 levels.

@article{Chang2015PhthalatesMI,
  title={Phthalates might interfere with testicular function by reducing testosterone and insulin-like factor 3 levels.},
  author={Wei-Hsiang Chang and Sih-syuan Li and M H Wu and H Pan and C C Lee},
  journal={Human reproduction},
  year={2015},
  volume={30 11},
  pages={2658-70}
}
STUDY QUESTION Do phthalates create a male reproductive hormone imbalance by down-regulating the secretion of testosterone and insulin-like factor 3 (INSL3)? SUMMARY ANSWER Our study suggests that exposure to phthalates is related to a reduction in the secretion of testosterone and INSL3 in adult males. WHAT IS KNOWN ALREADY There is evidence that exposure to phthalates, an abundant group of industrial plasticizers, negatively affects testosterone biosynthesis, but little is known about the… CONTINUE READING
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