Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.

@article{Matsuda2010PhthalateER,
  title={Phthalate esters reveal skin-sensitizing activity of phenethyl isothiocyanate in mice.},
  author={Tomoko Matsuda and Takashi Maruyama and Hiromi Iizuka and Ayumi Kondo and Takuma Tamai and Kohta Kurohane and Yasuyuki Imai},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2010},
  volume={48 6},
  pages={1704-8}
}
Phenethyl isothiocyanate (PEITC) is a constituent of edible cruciferous vegetables and has received attention due to its potential cancer chemopreventive activity. Although its protein-binding activity is known, PEITC has not been studied as a contact sensitizer. We previously demonstrated that phthalate esters, including dibutyl phthalate (DBP) and di-n-propyl phthalate (DPP), enhance skin sensitization in a fluorescein isothiocyanate (FITC)-induced contact hypersensitivity mouse model. In… CONTINUE READING

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Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association • 2014
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