Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.

@article{Fuller2001PhrenicLF,
  title={Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia.},
  author={D D Fuller and Andrea G Zabka and T L Baker and Gordon S Mitchell},
  journal={Journal of applied physiology},
  year={2001},
  volume={90 5},
  pages={2001-6; discussion 2000}
}
Episodic hypoxia evokes a sustained augmentation of respiratory motor output known as long-term facilitation (LTF). Phrenic LTF is prevented by pretreatment with the 5-hydroxytryptamine (5-HT) receptor antagonist ketanserin. We tested the hypothesis that 5-HT receptor activation is necessary for the induction but not maintenance of phrenic LTF. Peak integrated phrenic nerve activity (integralPhr) was monitored for 1 h after three 5-min episodes of isocapnic hypoxia (arterial PO(2) = 40 +/- 2… CONTINUE READING
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