Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats.

@article{Abbott2011Phox2bexpressingNO,
  title={Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats.},
  author={Stephen B G Abbott and Ruth L Stornetta and Melissa B. Coates and Patrice G Guyenet},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2011},
  volume={31 45},
  pages={16410-22}
}
The retrotrapezoid nucleus contains Phox2b-expressing glutamatergic neurons (RTN-Phox2b neurons) that regulate breathing in a CO₂-dependent manner. Here we use channelrhodopsin-based optogenetics to explore how these neurons control breathing in conscious and anesthetized adult rats. Respiratory entrainment (pacing) of breathing frequency (fR) was produced over 57% (anesthetized) and 28% (conscious) of the natural frequency range by burst activation of RTN-Phox2b neurons (3-8 × 0.5-20 ms pulses… CONTINUE READING
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PreBötzinger complex receives glutamatergic innervation from galaninergic and other retrotrapezoid nucleus neurons

  • G Bochorishvili, MB Coates, RL Stornetta, PG Guyenet
  • J Comp Neurol. Advance online publication…
  • 2011
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