Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development.

@article{Ke2015Phox2BCW,
  title={Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development.},
  author={Xiao-xue Ke and Dunke Zhang and Hailong Zhao and Renjian Hu and Zhen Dong and Rui Yang and Shunqin Zhu and Qingyou Xia and H T Ding and Hongjuan Cui},
  journal={Oncology letters},
  year={2015},
  volume={9 6},
  pages={2507-2514}
}
Neuroblastoma is the one of the most common extracranial childhood malignancies, accounting for ∼15% of tumor-associated deaths in children. It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla. However, the mechanism by which neuroblastoma arises during sympathetic neurogenesis and the cellular mechanism that drives neuroblastoma development remains unclear. The present study investigated the cell… CONTINUE READING

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It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla .
It is generally considered that neuroblastoma originates from neural crest cells in the paravertebral sympathetic ganglia and the adrenal medulla .
The present study demonstrates that paired - like homeobox 2b ( Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors .
In addition , Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state .
The present study demonstrates that paired - like homeobox 2b ( Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors .
In addition , Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state .
In addition , Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state .
The present study demonstrates that paired - like homeobox 2b ( Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors .
In addition , Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state .
The present study demonstrates that paired - like homeobox 2b ( Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors .
In addition , Phox2B+ neuronal progenitors in hyperplastic lesions or primary tumors were observed to be in an actively proliferative and undifferentiated state .
The present study demonstrates that paired - like homeobox 2b ( Phox2B)+ neuronal progenitors are the major cellular population in hyperplastic lesions and primary tumors .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
Neuroblastoma is the one of the most common extracranial childhood malignancies , accounting for ∼15% of tumor - associated deaths in children .
NeuroblastomaAssociated with malfunction of gene productMYCN protein, human
Phox2B correlates with MYCN and is a prognostic marker for neuroblastoma development .
MYCN geneGene associated with diseaseNeuroblastoma
The present study investigated the cell components during neuroblastoma development in the tyrosine hydroxylase - v - myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog ( TH - MYCN ) mouse model , a transgenic mouse model of human neuroblastoma .
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