Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damage.

@article{Yin2012PhototoxicityON,
  title={Phototoxicity of nano titanium dioxides in HaCaT keratinocytes--generation of reactive oxygen species and cell damage.},
  author={Jun-Jie Yin and Jun Liu and Marilyn Ehrenshaft and Joan E. Roberts and Peter P Fu and Ronald Paul Mason and Baozhong Zhao},
  journal={Toxicology and applied pharmacology},
  year={2012},
  volume={263 1},
  pages={81-8}
}
Nano-sized titanium dioxide (TiO(2)) is among the top five widely used nanomaterials for various applications. In this study, we determine the phototoxicity of TiO(2) nanoparticles (nano-TiO(2)) with different molecular sizes and crystal forms (anatase and rutile) in human skin keratinocytes under UVA irradiation. Our results show that all nano-TiO(2) particles caused phototoxicity, as determined by the MTS assay and by cell membrane damage measured by the lactate dehydrogenase (LDH) assay… CONTINUE READING