Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

  title={Phototoxicity and Environmental Transformation of Polycyclic Aromatic Hydrocarbons (PAHs)—Light-Induced Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage},
  author={Peter P. Fu and Qingsu Xia and Xin Sun and Hongtao Yu},
  journal={Journal of Environmental Science and Health, Part C},
  pages={1 - 41}
  • P. Fu, Q. Xia, Hongtao Yu
  • Published 1 January 2012
  • Chemistry, Biology
  • Journal of Environmental Science and Health, Part C
Polycyclic aromatic hydrocarbons (PAHs) are a class of mutagenic and tumorigenic environmental contaminants. Although the mechanisms by which PAHs induce cancer in experimental animals have been extensively studied and the metabolic activation pathways have been determined, the environmental fate of PAHs and the phototoxicity exerted by PAHs, as well as their photoreaction products formed in the environment, have received much less attention. In this review, the formation of oxygenated PAHs… 

UVA Photoirradiation of Nitro-Polycyclic Aromatic Hydrocarbons—Induction of Reactive Oxygen Species and Formation of Lipid Peroxides †

The results indicated that all but two of the nitro-PAHs can induce lipid peroxidation, andMechanistic studies suggest that lipid per oxidation by nitro, polycyclic aromatic hydrocarbons is mediated by free radicals generated in the reaction.

Metal-Polycyclic Aromatic Hydrocarbon Mixture Toxicity in Hyalella azteca. 2. Metal Accumulation and Oxidative Stress as Interactive Co-toxic Mechanisms.

No evidence is found to suggest that interactive effects on ROS production were involved in the more-than-additive mortality of Cu-PHE and Cu- PHQ mixtures, however, PHQ increased the tissue concentration of Cu in juvenile H. azteca, providing a potential mechanism for the observed more- Than-Additive mortality.

Analytical chemistry, formation, mitigation, and risk assessment of polycyclic aromatic hydrocarbons: From food processing to in vivo metabolic transformation.

It is important to reduce dietary PAH exposure and to implement reasonable and effective risk management strategies to reduce PAH levels in food to improve public health.

Mechanism of unprecedented hydroxyl radical production and site-specific oxidative DNA damage by photoactivation of the classic arylhydroxamic acid carcinogens.

This represents the first report of •OH production and site-specific DNA damage via photoactivation of the genotoxic hydroxamic acid intermediate, which provides a new free radical perspective to better understand the molecular mechanism for the carcinogenicity of AAs.

Polycyclic Aromatic Acids Are Primary Metabolites of Alkyl-PAHs-A Case Study with Nereis diversicolor.

It is proposed that carboxylic acid metabolites of alkyl-PAHs have the potential of constituting a new class of contaminants in marine waters that needs attention in relation to ecological risk assessments.

Remediation of Polycyclic Aromatic Hydrocarbons Using Nanomaterials

Polycyclic aromatic hydrocarbons are major contaminants in environmental bodies due to ubiquitous occurrence, toxicity and potential to bioaccumulation. Increased population, rapid industrialization



Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation

It is suggested that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation, which leads to PAH genotoxicity.

Photoirradiation of polycyclic aromatic hydrocarbons with UVA light - a pathway leading to the generation of reactive oxygen species, lipid peroxidation, and dna damage.

  • Hongtao YuQ. Xia P. Fu
  • Chemistry, Biology
    International journal of environmental research and public health
  • 2006
The study of photoirradiation of PAHs with UVA irradiation results in cytotoxicity and DNA damage and evidence has been shown that these photobiological activities are mediated by reactive oxygen species (ROS).

Photoinduced toxicity of polycyclic aromatic hydrocarbons to Daphnia magna: ultraviolet-mediated effects and the toxicity of polycyclic aromatic hydrocarbon photoproducts.

The data presented highlight the effects of ultraviolet radiation on mediating PAH toxicity and the need to analyze absorption spectra of contaminants in the prediction of photoinduced toxicity.

UVA Photoirradiation of Oxygenated Benz[a]anthracene and 3-Methylcholanthene - Generation of Singlet Oxygen and Induction of Lipid Peroxidation

The overall results suggest that UVA photoirradiation of oxygenated BA and 3-methylcholanthrene generates singlet oxygen, one of the reactive oxygen species (ROS), which induce lipid peroxidation.


  • Hongtao Yu
  • Chemistry
    Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews
  • 2002
An up-to-date source of photochemical reaction, photo-transformation, and phototoxicity of PAHs and their oxygenated, nitrated, halogenated, and amino substituted derivatives on a molecular basis is provided.

UVA Photoirradiation of Halogenated-Polycyclic Aromatic Hydrocarbons Leading to Induction of Lipid Peroxidation

Researchers study the photoirradiation of a series of structure-related halo-PAHs by UVA light in the presence of a lipid, methyl linoleate, and determine as to whether or not these compounds can induce lipid peroxidation.

UVA Photoirradiation of Methylated Benzo[a]pyrene and Benzo[e]pyrene leading to Induction of Lipid Peroxidation

  • D. SáenzQ. XiaP. Fu
  • Chemistry
    International journal of environmental research and public health
  • 2007
It is suggested that photoirradiation of MBaPs and MBePs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

Benzo[a]Pyrene Diones are Produced by Photochemical and Enzymatic Oxidation and Induce Concentration-Dependent Decreases in the Proliferative State of Human Pulmonary Epithelial Cells

A role for PAH oxidation products (PAH diones) in the adverse health effects associated with combustion-derived PM and semivolatile organic compounds is indicated.

Effect of Organic Solvents and Biologically Relevant Ions on the Light-Induced DNA Cleavage by Pyrene and Its Amino and Hydroxy Derivatives

Abstract: Polycyclic aromatic hydrocarbons (PAH s) are a class of carcinogenic compounds that are both naturally and artificially produced. Many PAHs are pro-carcinogens that re-quire metabolic