Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy.

@article{Matera2018PhotoswitchableAF,
  title={Photoswitchable Antimetabolite for Targeted Photoactivated Chemotherapy.},
  author={Carlo Matera and Alexandre M. J. Gomila and N{\'u}ria Camarero and Michela Libergoli and Concepci{\'o} Soler and Pau Gorostiza},
  journal={Journal of the American Chemical Society},
  year={2018},
  volume={140 46},
  pages={
          15764-15773
        }
}
The efficacy and tolerability of systemically administered anticancer agents are limited by their off-target effects. Precise spatiotemporal control over their cytotoxic activity would allow improving chemotherapy treatments, and light-regulated drugs are well suited to this purpose. We have developed phototrexate, the first photoswitchable inhibitor of the human dihydrofolate reductase (DHFR), as a photochromic analogue of methotrexate, a widely prescribed chemotherapeutic drug to treat cancer… 

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