Photosensitizer-Encapsulated Ferritins Mediate Photodynamic Therapy against Cancer-Associated Fibroblasts and Improve Tumor Accumulation of Nanoparticles.

@article{Li2018PhotosensitizerEncapsulatedFM,
  title={Photosensitizer-Encapsulated Ferritins Mediate Photodynamic Therapy against Cancer-Associated Fibroblasts and Improve Tumor Accumulation of Nanoparticles.},
  author={Lu Li and Shiyi Zhou and NingNing Lv and Zipeng Zhen and Tianji Liu and Shi Gao and Jin Y. Xie and Qingjie Ma},
  journal={Molecular pharmaceutics},
  year={2018},
  volume={15 8},
  pages={
          3595-3599
        }
}
Nanoparticles have been widely tested as drug delivery carriers or imaging agents, largely because of their ability to selectively accumulate in tumors through the enhanced permeability and retention (EPR) effect. However, studies show that many tumors afford a less efficient EPR effect and that many nanoparticles are trapped in the perivascular region after extravasation and barely migrate into tumor centers. This is to a large degree attributed to the dense tumor extracellular matrix (ECM… CONTINUE READING
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