Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa.

@article{Reszka2006PhotosensitizedOA,
  title={Photosensitized oxidation and inactivation of pyocyanin, a virulence factor of Pseudomonas aeruginosa.},
  author={Krzysztof J Reszka and Gerene M. Denning and Bradley E. Britigan},
  journal={Photochemistry and photobiology},
  year={2006},
  volume={82 2},
  pages={466-73}
}
Pyocyanin (PyO-) (1-hydroxy-5-methylphenazine) is a cytotoxic compound secreted by Pseudomonas aeruginosa, an omnipresent bacterium and a human pathogen. We report that visible light illumination in the presence of rose bengal, or riboflavin, in aerated solutions (pH 7.0-7.2) induces irreversible loss of the pigment's characteristic absorption band at 690 nm, indicating its oxidation. This photobleaching was paralleled by generation of a multiline Electron Paramagnetic Resonance (EPR) spectrum… CONTINUE READING
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