Photosensitized inhibition of growth factor-regulated protein kinases by hypericin.

@article{Agostinis1995PhotosensitizedIO,
  title={Photosensitized inhibition of growth factor-regulated protein kinases by hypericin.},
  author={Patrizia Agostinis and A L Vandenbogaerde and Arianna Donella-Deana and Lorenzo A Pinna and Kyung-won Lee and Jozef Goris and Wilfried Merlevede and Jackie R. Vandenheede and Peter A. M. de Witte},
  journal={Biochemical pharmacology},
  year={1995},
  volume={49 11},
  pages={1615-22}
}
The naphthodianthrone hypericin causes a photosensitized inhibition of protein kinases involved in growth factor signalling pathways. Nanomolar concentrations of hypericin inhibit the protein tyrosine kinase activities (PTK) of the epidermal growth factor receptor and the insulin receptor, while being ineffective towards the cytosolic protein tyrosine kinases Lyn, Fgr, TPK-IIB and CSK. Photosensitized inhibition by hypericin is not restricted to receptor-PTKs since the Ser/Thr protein kinases… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Modulation of HIV-1 infectivity by MAPK, a virion-associated kinase.

The EMBO journal • 1998
View 2 Excerpts
Highly Influenced

Photodynamic therapy of cerebral glioma--a review Part I--a biological basis.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia • 2006

Similar Papers

Loading similar papers…